Clinical Research Method for the Fast, Efficient Analysis of Mycophenolic Acid Utilizing Online Solid-Phase Extraction in Conjunction with UPLC/MS/MS
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چکیده
■ Efficient sample clean-up resulting in better analytical results and system robustness IN T RO DU C T IO N Mycophenolic acid is a drug that interferes with purine nucleotide synthesis required for the proliferative response of T and B cells. Measurement of drug levels in plasma can be performed by a variety of analytical methods including immunoassay, LC with UV detection, or LC/MS. LC/MS methods can provide a level of analytical sensitivity and selectivity for mycophenolic acid analysis that is difficult for other methods to achieve.
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تاریخ انتشار 2013